Our research program focuses on the role of the intestine in disease. Because the intestine is responsible for dietary fat absorption, and atherogenic chylomicron secretion, it’s a tissue that contributes to metabolic disease. On the other hand, the intestine maintains a barrier to dietary and bacterial pathogens, and promotes tolerogenic immunity. As such, the intestine and its proteins are critical for protection from inflammatory diseases. The overall goal of this research is to identify mechanisms in the intestine that can be exploited as therapeutic strategies for treating inflammatory bowel disease and metabolic disease.