Major efforts in our lab focus on:
(i) mechanism of apoC-III regulation of intestinal regulatory T cells (Tregs)
(ii) the interplay between dietary lipid absorption and inflammatory bowel disease
(iii) the influence of plasma lipoproteins, particularly triglyceride-rich lipoproteins with apoCIII, on intestinal lipid metabolism.
The Kohan Lab has expertise in intestinal lipid absorption, lipoprotein synthesis and secretion, lipid and lipoprotein metabolism, and the primary intestinal organoid model for the study of lipoprotein synthesis and secretion.